Pedstrip: extracting a maximal subset of available, unrelated individuals from a pedigree
نویسندگان
چکیده
UNLABELLED Certain types of genetic analysis are simplified by assembling a collection of unrelated individuals, e.g. case-control experiments. If a family study is being performed then it will be necessary to extract subsets of unrelated, available individuals from pedigress. Our program provides an optimal method for performing this task. AVAILABILITY The software is available, free of charge, on request from Oxagen Ltd. SUPPLEMENTARY INFORMATION http://www.oxagen.co.uk
منابع مشابه
PedMine - a simulated annealing algorithm to identify maximally unrelated individuals in population isolates
UNLABELLED In family-based genetic studies, it is often useful to identify a subset of unrelated individuals. When such studies are conducted in population isolates, however, most if not all individuals are often detectably related to each other. To identify a set of maximally unrelated (or equivalently, minimally related) individuals, we have implemented simulated annealing, a general-purpose ...
متن کاملAssociation analysis of whole genome sequencing data accounting for longitudinal and family designs
Using the whole genome sequencing data and the simulated longitudinal phenotypes for 849 pedigree-based individuals from Genetic Analysis Workshop 18, we investigated various approaches to detecting the association of rare and common variants with blood pressure traits. We compared three strategies for longitudinal data: (a) using the baseline measurement only, (b) using the average from multip...
متن کاملROADTRIPS: case-control association testing with partially or completely unknown population and pedigree structure.
Genome-wide association studies are routinely conducted to identify genetic variants that influence complex disorders. It is well known that failure to properly account for population or pedigree structure can lead to spurious association as well as reduced power. We propose a method, ROADTRIPS, for case-control association testing in samples with partially or completely unknown population and ...
متن کاملبرآورد صحت انتخاب ژنومی در جوامع کوچک ژنتیکی- مطالعه شبیهسازی
In the present study two genetically connected small and large populations were simulated and the effect of different sources of information from foreign populations on the accuracy of predicted genomic breeding values of young animals of the small population was investigated. A large population consist of 200000 animals over 15 generations and a small population consist of 5000 animals over 3 ...
متن کاملMaximal subsets of pairwise non-commuting elements of some finite p-groups
Let G be a group. A subset X of G is a set of pairwise noncommuting elements if xy ̸= yx for any two distinct elements x and y in X. If |X| ≥ |Y | for any other set of pairwise non-commuting elements Y in G, then X is said to be a maximal subset of pairwise non-commuting elements. In this paper we determine the cardinality of a maximal subset of pairwise non-commuting elements in any non-abelian...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Bioinformatics
دوره 19 2 شماره
صفحات -
تاریخ انتشار 2003